A small bioactive glycoside inhibits epsilon toxin and protects host cell death
نویسندگان
چکیده
منابع مشابه
Peruvoside, a Cardiac Glycoside, Induces Primitive Myeloid Leukemia Cell Death.
Despite the available chemotherapy and treatment, leukemia remains a difficult disease to cure due to frequent relapses after treatment. Among the heterogeneous leukemic cells, a rare population referred as the leukemic stem cell (LSC), is thought to be responsible for relapses and drug resistance. Cardiac glycosides (CGs) have been used in treating heart failure despite its toxicity. Recently,...
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Clostridium perfringens type B or D isolates, which cause enterotoxemias or enteritis in livestock, produce epsilon toxin (ETX). ETX is exceptionally potent, earning it a listing as a CDC class B select toxin. Most C. perfringens strains also express up to three different sialidases, although the possible contributions of those enzymes to type B or D pathogenesis remain unclear. Type D isolate ...
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ژورنال
عنوان ژورنال: Disease Models & Mechanisms
سال: 2019
ISSN: 1754-8411,1754-8403
DOI: 10.1242/dmm.040410